DSIP

What it is

DSIP was isolated in 1977 by Schoenenberger and Monnier from the blood of rabbits in which deep, slow-wave sleep had been induced. It was named for its apparent ability to promote delta-wave sleep.

How it works

No specific receptor has been identified. Research has linked it to effects on stress hormones, body temperature and pain, but how it works remains unclear.

What the research shows

• Early human studies in insomnia produced inconsistent results.
• Some small studies looked at withdrawal symptoms and stress responses.
• Decades of research have not established a clear sleep benefit.

Regulatory status

Not FDA-approved. In July 2026 the FDA's Pharmacy Compounding Advisory Committee voted 7 to 6 against recommending DSIP for the compounding bulks list. It was the only peptide of the seven reviewed that the committee did not support.

Storage and handling

Lyophilized (freeze-dried) powder is most stable sealed, dry and protected from light. Laboratory practice is to keep unopened vials frozen at about -20 °C for long-term storage, or refrigerated at 2 to 8 °C for shorter periods. After reconstitution, keep the solution refrigerated at 2 to 8 °C, avoid repeated freeze-thaw cycles and use aseptic technique for every draw. Formal stability data in solution has not been published for most research peptides, so follow the supplier's label and certificate of analysis.

Reconstitution math

To work out concentration, volume and U-100 syringe units for any vial size, use the reconstitution calculator with DSIP selected. Always confirm the vial content against the label and the batch's certificate of analysis.

Key references

• Schoenenberger GA, Monnier M. Characterization of a delta-electroencephalogram (-sleep)-inducing peptide. Proc Natl Acad Sci USA. 1977.
• Search PubMed for DSIP studies

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