What it is
SLU-PP-332 is a synthetic small molecule developed in Thomas Burris's laboratory at Saint Louis University. It is not a peptide, though it is often sold alongside them. It activates the estrogen-related receptors (ERRα, ERRβ and ERRγ), with the strongest activity at ERRα.
How it works
ERRs are nuclear receptors that switch on genes for mitochondrial growth and fatty-acid oxidation, the same programs that endurance exercise activates in muscle. Activating them pharmacologically is meant to reproduce part of that training response.
What the research shows
- In mice, SLU-PP-332 increased the proportion of oxidative muscle fibers and improved treadmill endurance.
- In obese mice it reduced fat gain and improved insulin sensitivity.
- No human studies have been published.
Regulatory status
Not approved for any use. It is a preclinical research compound only.
Storage and handling
Store the dry powder sealed, cool and protected from light. Small molecules like this are usually dissolved in an organic solvent such as DMSO for laboratory work rather than bacteriostatic water; follow the supplier's documentation.
Key references
- Billon C et al. Synthetic ERRα/β/γ agonist induces an ERRα-dependent acute aerobic exercise response and enhances exercise capacity. ACS Chem Biol. 2023.
- Search PubMed for SLU-PP-332 studies
Peptide Knowledge is an educational reference. Nothing on this site is medical advice, a treatment recommendation or dosing guidance. Many compounds described here are not approved for human use and are sold for laboratory research only. Talk to a licensed clinician before starting, stopping or changing any medication or supplement.
Related compounds
Related reading: reconstitution guide · how to read a certificate of analysis